NITRIC OXIDE (NO) is present in the human airway, 1 and high nasal concentrations of nitric oxide were first detected by Alving et al. These results suggest an important alternative source of nitric oxide in humans. Peak nasal nitric oxide values after accumulation are similar to published sinus nitric oxide measurements obtained by direct puncture. The accumulated nitric oxide peak increased in direct proportion to the accumulation time ( P<.001).Ĭonclusions Nitric oxide concentrations accumulate in the nonventilated nasal cavity in proportion to the time of nonventilation. There was no significant difference between initial and second plateau nitric oxide levels for any period. On opening to the analyzer after the accumulation period, the peak nitric oxide level was several times higher than the initial plateau (range, 2810-19,008 ppb) and then slowly returned to previous plateau levels. Results While the subjects aspirated air at a constant flow, there was a slow rise to a first nitric oxide plateau. After varying occlusion times, peak nitric oxide levels and a second plateau were ascertained. Nitric oxide was then allowed to accumulate in the nasal cavity by occluding both nares and keeping the velum closed. Methods In 9 healthy subjects previously trained to close the soft palate, steady-state plateau nitric oxide levels were recorded while air was aspirated through the nasal airway in series at a constant flow rate. Objective To explore the rate of nitric oxide accumulation in the nonventilated nasal cavity. Shared Decision Making and Communicationīackground Nasal nitric oxide is present in high concentrations in the upper airway relative to the lower respiratory tract.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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